Widespread Genetic Engineering
Genetic engineering techniques are now cheap and widespread enough that any knowledgeable individual can order every material they need off the Internet and download the software to do their own experiments on themselves. Everyone in citizen science and the biohacker community has stories of being contacted by trainers, coaches, and athletes. There is absolutely no way to regulate it, and if you tried to it would be like stemming the tide with a fork.
Biotechnology & Bioinformatics Chair, Singularity University